Premium
Comparative pharmacokinetics of tobramycin and gentamicin
Author(s) -
Regamey Claude,
Gordon Ralph C.,
Kirby William M. M.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973143396
Subject(s) - tobramycin , aminoglycoside , pharmacokinetics , gentamicin , liter , volume of distribution , urine , intramuscular injection , antibiotics , renal function , medicine , pharmacology , anesthesia , chemistry , biochemistry
Blood and urine concentrations of a new aminoglycoside, tobramycin, were compared with those of gentamicin after intravenous and intramuscular administration in healthy adult volunteers. Serum concentrations for the two antibiotics were the same after an intravenous infusion of 100 mg for the first haur (about 4.75 p.g per milliliter), during the steady state attained by infusing 30 mg per hour for the next 2 haurs (about 3.85 p.g per milliliter), and during the elimination phase after the antibiotics were stopped. After a single intramuscular injection of 100 mg, the blood level curves were equal and the peak concentrations at 20 to 45 minutes were the same as those obtained after intravenous infusion of the same dose for 1 hour. Between 80% and 90% of each of the two antibiotics was recovered in the urine within 24 hours. Plasma clearance was not significantly higher than renal clearance, and glomerular filtration seemed to be the main pathway of elimination. The two aminoglycosides had an apparent volume of distribution of about 30% total body weight. Each had a half‐life of 2 hours.