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Effects of orally administered delta‐9‐tetrahydrocannabinol in man
Author(s) -
Hosko M. J.,
Kochar M. S.,
Wang R. I. H.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973143344
Subject(s) - δ9 tetrahydrocannabinol , delta 9 tetrahydrocannabinol , placebo , anesthesia , hyperreflexia , tetrahydrocannabinol , hallucinogen , electrooculography , psychology , medicine , reflex , audiology , electroencephalography , pharmacology , cannabinoid , neuroscience , alternative medicine , receptor , pathology
The etfects of Δ 9 ‐tetrahydrocannabinol (Δ 9 ‐THC) administered orally at 2 dose levels were studied in a group of 7 healthy young adult males. Each subiect was studied for 7 nights (2 drug, 5 placebo). Vital signs, subiective feelings, deep tendon reflexes, electrocardiogram, electroencephalogram, visual evoked responses, postural responses, time estimation and reaction time and sleep patterns were studied. At the doses studied, Δ 9 ‐THC increased pulse rate, altered subjective feelings, and caused hyperreflexia and upset postural responses in the absence of visual cues. Some subjects also exhibited lowered oral temperature, changes in averaged visual evoked response, and alteration of sleep patterns.