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Respiratory effects of hydromorphone in man
Author(s) -
Brown Colin R.,
Forrest William H.,
Hayden Johan,
James Kenneth E.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973143331
Subject(s) - hydromorphone , morphine , anesthesia , potency , medicine , respiratory system , depression (economics) , depressant , population , pharmacology , opioid , chemistry , receptor , biochemistry , environmental health , economics , in vitro , macroeconomics
The respiratory depressant efJeets of hydromorphone, a potent analgesie, were compared with morphine in a randomized double‐blind erossover study in human volunteers. Using a rebreathing technique, earbon dioxide response curves were plotted automatically with a speeial‐purpose analog computer. The respiratory depressant relative potency of hydromorphone to morphine over the total observation period was found to be 7.99 with lower and upper 95 per cent confidence limits of 5.44 and 10.69. Based on the displacement of the respiratory response curve, approximately 1.25 mg of hydromorphone is equivalent to 10 mg of morphine in our population of volunteers. For peak respiratorll depression, 0.95 mg of hydromorphone is equivalent to 10 mgoj morphine