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Bioavailability of potassium from a slow‐release tablet
Author(s) -
BenIshay Drori,
Engelman Karl
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973142250
Subject(s) - bioavailability , potassium , urine , postprandial , chemistry , oral administration , taste , pharmacology , zoology , endocrinology , medicine , food science , biochemistry , organic chemistry , insulin , biology
The bioavailability of potassium (K) from orally administered 10 per cent potassium chloride (KCI) solution has been compared with that from a slow‐release KCl tablet (Slow‐K) in 10 normal subiects under metabolic balance conditions. After a single 40 mEq. KCl dose, urinary K increased sooner and to greater peak levels after the solution was administered. In both cases greater amounts of K appeared in the urine when administered in the fasting than in the postprandial state. In 4 days of administration there was no difference in the net increment in urine K produced by equivalent doses of either preparation. No significant toxicity was experienced with either preparation. The unpleasant taste of the KCI solution was noted by each subject.