Premium
Gastrointestinal blood loss from aspirin and sodium salicylate tablets in man
Author(s) -
Leonards Jack R.,
Levy Gerhard
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197314162
Subject(s) - aspirin , salicylic acid , sodium salicylate , antacid , blood loss , medicine , chemistry , pharmacology , bleeding time , sodium , anesthesia , surgery , biochemistry , platelet , platelet aggregation , organic chemistry
In view of conflicting reports on gastrointestinal blood loss produced by aspirin, sodium salicylate, and salicylic acid, a rigorously controlled comparative study has been carried out. Thirteen healthy adult volunteers took twelve 325 mg. aspirin or sodium salicylate tablets (plain and with antaCid) daily for 7 day periods in a crossover study. The 3 preparations produced similar steady state plasma‐salicylate concentrations. Sodium salicylate tablets caused gastrointestinal blood loss (1.2 ml. per day above control values), but the blood loss produced by aspirin tablets was appreciably greater (5.6 ml. per day above control values). However, other studies have shown that aspirin‐induced gastrointestinal bleeding can be minimized by use of specially formulated dosage forms.