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Pharmacokinetic studies of practolol, a beta adrenergic antagonist, in man
Author(s) -
Bodem Gunter,
Chidsey Charles A.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197314126
Subject(s) - practolol , volume of distribution , pharmacokinetics , urine , pharmacology , distribution volume , distribution (mathematics) , chemistry , urinary system , clearance , creatinine , medicine , endocrinology , urology , mathematical analysis , mathematics , propranolol
The disposition of practolol after oral and intravenous administration was studied in hypertensive patients. The plasma half‐life was 13.2 hours. After intravenous administration practolol was recovered quantitively in the urine. Its volume of distribution was larger than that of body water, 1.6 L. per kilogram, and its clearance from this volume, 135 ml. per minute, was equal to renal clearance of the drug; both were slightly higher than the creatinine clearance. Despite its weakly basic character, this aromatic alkylamine was not affected by changes in urinary pH from 5.4 to 8.0. These studies indicate that practolol is slowly removed from the body and that it is excreted entirely by the kidneys.