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Uptake and distribution of thiopental after oral, rectal, and intramuscular administration: Effect of hepatic metabolism and injection site blood flow
Author(s) -
Saidman Lawrence J.,
Eger Edmond I.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197314112
Subject(s) - oral administration , blood flow , medicine , intramuscular injection , route of administration , metabolism , rectal administration , drug metabolism , anesthesia , pharmacokinetics , rectum
The effects of hepatic metabolism and iniection site blood flow on blood and brain thiopental concentrations following oral, rectal, and intramuscular administration were evaluated using a digital computer programmed with input data from an idealized electrical model. Peak drug levels were increased with high injection site flow rates and decreased with high rates of metabolism. The position of the liver relative to the iniection site was important in decreasing drug levels approximately twice as much after oral than after intramuscular administration. Altered hepatic function (increased or decreased) will affect blood and tissue thiopental levels more after oral or rectal administration than after intramuscular or intravenous administration.