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Comparative study of tobramycin and gentamicin with special reference to anti‐Pseudomonas activity
Author(s) -
Klastersky J.,
Daneau D.,
de Maertelaer V.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973141104
Subject(s) - tobramycin , gentamicin , pseudomonas aeruginosa , liter , aminoglycoside , microbiology and biotechnology , pseudomonas , antibiotics , medicine , chemistry , biology , bacteria , genetics
Tobramycin was compared to gentamicin in vitro and was found more active on Pseudomonas aeruginosa. When tobramycin and gentamicin were administered to volunteers as a single intramuscular iniection (2 .. 5 mg. per kilogram), similar blood levels were observed (mean peak levels of 7.3 p.g per milliliter and 7.1 p.g per milliliter, respectively). Sera from these subiects was more active (p < 0.05) against strains of Ps. aeruginosa, which had similar susceptibility to tobramycin and gentamicin.