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Enhancement of warfarin‐induced hypoprothrombinemia by triclofos
Author(s) -
Sellers Edward M.,
Lang Mary,
Koch-Weser Jan,
Colman Robert W.
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972136911
Subject(s) - hypoprothrombinemia , warfarin , prothrombin time , warfarin sodium , pharmacology , medicine , chemistry , metabolite , phenobarbital , anesthesia , vitamin k , atrial fibrillation
Daily administration of hypnotic doses of triclofos (trichloroethyl sodium phosphate) significantly prolonged prothrombin time in 7 volunteers chronically anticoagulated with warfarin. Mean sensitivity to warfarin (prothrombin time prolongation/cumulative 72 hour warfarin dose) increased by 49 per cent during the first week of triclofos therapy. Plasma concentrations of factors II and X fell within 9 hours of a single dose of triclofos. A metabolite of triclofos, trichloroacetic acid, accumulated in plasma to 80 µg per milliliter during one week of triclofos administration. The displacement of warfarin from human albumin by trichloroacetic acid can account for the potentiation of warfarin action by triclofos.