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Effect of aspirin, caffeine, and codeine on the metabolism of phenacetin and acetaminophen
Author(s) -
Thomas Barry H.,
Coldwell Blake B.,
Zeitz W.,
Solomonraj G.
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972136906
Subject(s) - phenacetin , acetaminophen , codeine , caffeine , aspirin , urine , metabolism , pharmacology , analgesic , chemistry , antipyretic , medicine , morphine , biochemistry
The metabolism of phenacetin (P) and acetaminophen (A') alone and with aspirin (A), caffeine (C), and codeine (C') (APCC' and AA'CC') was studied in 24 human volunteers. The principle route of phenacetin metabolism and the total obsorption of phenacetin were not affected by the drug combination. The proportion of the dose of phenacetin metabolized to 2‐hydl'Oxyphenetidine (2‐0HP) was increased from 1.9 to 3.4 per cent when APCC' was ingested. Large individual variations in the amounts of 2‐0HP excreted were observed. The changes produced in the metabolism of acetaminophen when it was taken as AA'CC' were minor. No 2‐0HP was detected after administration of acetaminophen. No changes in blood and urine were observed with any of the drug treatments.