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Effect of renal failure and hemodialysis on cephacetrile pharmacoki netics
Author(s) -
Nissenson Allen R.,
Levin Nathan W.,
Parker Richard H.
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972136887
Subject(s) - renal function , cephaloridine , cephalosporin , nephrotoxicity , filtration fraction , medicine , urine , renal physiology , hemodialysis , excretion , urology , endocrinology , plasma clearance , antibiotics , chemistry , kidney , pharmacokinetics , renal blood flow , biochemistry
Cephacetrile, a new injectable cephalosporin antibiotic that is allegedly not nephrotoxic, was evaluated in 15 subjects with varying degrees of renal functional impairment Cephacetrile has a serum half‐life of 1.3 hours in normal subjects which depends on the glomerular filtration rate. The total plasma clearance rate and the renal clearance rate of cephacetrile are high compared with the clearance rates of other cephalosporins, so also is the fraction of the injected dose excreted in the urine. Renal excretion of cephacetrile is accomplished by glomerular filtration and tubular secretion in normal subjects, but in patients with renal failure there is little evidence of tubular secretion. Cephacetrile is partially dialyzable, but higher serum levels during hemodialysis are noted after a standard dose than are expected after a similar dose of cephalothin or cephaloridine.