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The effect of guancydine on blood pressure, vascular reactivity, and norepinephrine uptake in essential hypertension
Author(s) -
Russo Carlo,
Mendlowitz Milton
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972136875
Subject(s) - norepinephrine , supine position , blood pressure , vascular smooth muscle , medicine , endocrinology , reactivity (psychology) , chemistry , anesthesia , smooth muscle , pathology , dopamine , alternative medicine
Guancydine was administered to 10 patients for a period of 3 weeks to 6 months. The drug produced a decrease in both supine and standing blood pressures as well as in digital vascular reactivity but caused no change in tritiated norepinephrine uptake. Its action appears to be direct inhibition of vascular smooth muscle. Side effects were minimal and transitory.