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The levels of methadone in the plasma in methadone maintenance
Author(s) -
Inturrisi Charles E.,
Verebely Karl
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972135part1633
Subject(s) - methadone , liter , methadone maintenance , medicine , plasma levels , anesthesia , half life , pharmacokinetics
The time course of methadone in the plasma of 5 methadone maintenance subjects receiving a single daily oral dose of 100 or 120 mg. has been determined. The predose mean plasma level of methadone was 0.48 fig per milliliter. The peak plasma level occurred at 4 hours with an average value of 0.86 fig per milliliter. This level slowly declined so that 24 hours after administration the mean plasma level had reached a value (0.46 fig per milliliter) approximately equal to the predose level. The mean apparent half‐life of methadone in these sub;ects was 25 hours. Data on the renal clearance of methadone indicate that the drug is partially reabsorbed by the kidney and that this reabsorption is pH dependent.