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Plasma urea kinetics in urea infusion
Author(s) -
Yarnell Philip R.,
Bell Richard L.,
Ng Paul,
Gormley William T.
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972134558
Subject(s) - urea , compartment (ship) , kinetics , extracellular fluid , fluid compartments , chemistry , extracellular , zoology , biochemistry , biology , oceanography , physics , quantum mechanics , geology
Seven patients undergoing an infusion of 30 per cent urea‐10 per cent invert sugar solution (Urevert) for treatment of cerebral edema were studied with regard to plasma urea kinetics. The 2 compartment (extracellular and intracellular fluid spaces) model has been applied to analysis of the plasma levels. On the average, the human data could be simulated with our standard canine correlation: 2 compartment urea transport coefficient K, (liters per hour)= 0.735 weight (kilograms)± 14 per cent.