Premium
Fibrinolytic activity and thromboembolism
Author(s) -
Boyles Paul W.
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972134534
Subject(s) - fibrinolysis , medicine , thromboembolic disease , fibrinolysin , fibrin , titer , cardiology , gastroenterology , thrombosis , immunology , plasmin , antibody , chemistry , biochemistry , enzyme
Fibrinolysis is reduced in acute thromboembolism. Titers of fibrinolysin inhibitor vary diurnally in the same directions and to the same degree as in the sex‐ and age‐matched normal control subject, but always within a higher range. The acute thromboembolic episode apparently involves an initial fall in inhibitor, followed by a gradual rise to an abnormally elevated plateau. If this occurs consistently, it may prove useful as a further means of recognizing and monitoring the thromboembolic episode. No correlation was demonstrated between the titer of fibrin degradation products and the degree of reduction in fibrinolytic activity after acute thromboembolism.