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Analgesic and other effects of nalmexone in man
Author(s) -
Forrest William H.,
Shroff Phyllis F.,
Mahler Donald L.
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972134520
Subject(s) - analgesic , oxymorphone , morphine , potency , sedation , anesthesia , medicine , pharmacology , opioid , chemistry , biochemistry , oxycodone , receptor , in vitro
Analgesic and other effects of nalmexone, an n‐dimethylallyl derivative of oxymorphone, were compared with those of morphine in 451 surgical patients in 2 hospital members of the VA Cooperative Analgesic Study. Based on total analgesia for a 255 minute observation period, relative potency estimates indicated that 70 to 90 mg. of nalmexone was equivalent to 10 mg. of morphine. Sedation and, to a lesser extent, sweating were frequent effects of both drugs.