Analgesic and other effects of nalmexone in man | Zendy

Forrest William H. | Zendy; Shroff Phyllis F. | Zendy; Mahler Donald L. | Zendy

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Analgesic and other effects of nalmexone in man

Author(s) -

Forrest William H.,

Shroff Phyllis F.,

Mahler Donald L.

Publication year - 1972

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt1972134520

Subject(s) - analgesic , oxymorphone , morphine , potency , sedation , anesthesia , medicine , pharmacology , opioid , chemistry , biochemistry , oxycodone , receptor , in vitro

Analgesic and other effects of nalmexone, an n‐dimethylallyl derivative of oxymorphone, were compared with those of morphine in 451 surgical patients in 2 hospital members of the VA Cooperative Analgesic Study. Based on total analgesia for a 255 minute observation period, relative potency estimates indicated that 70 to 90 mg. of nalmexone was equivalent to 10 mg. of morphine. Sedation and, to a lesser extent, sweating were frequent effects of both drugs.

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