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Effect of triamterene on the renal clearance of calcium, magnesium, phosphate, and uric acid in man
Author(s) -
Walker Barry R.,
Hoppe Robert C.,
Alexander Fred
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972132245
Subject(s) - triamterene , chemistry , endocrinology , uric acid , calcium , medicine , magnesium , reabsorption , renal physiology , diuretic , hyperuricemia , renal function , creatinine , sodium , urine , excretion , kidney , biochemistry , hydrochlorothiazide , blood pressure , organic chemistry
Triamterene administered for 2 weeks to 16 normal volunteers increased the renal clearance of sodium and magnesium without affecting calcium or phosphate excretion. It decreased the uric acid clearance in proportion to the decrease in creatinine clearance. Triamterene induced no significant change in serum calcium, phosphate, or uric acid, but there was a slight increase in serum magnesium. The results support the hypothesis that sodium transport in the distal tubule can be inhibited without affecting calcium reabsorption. The mechanism for the increased blood and urine magnesium is not known but could be both renal and extrarenal. There was no evidence for an inhibition of tubular secretion of uric acid. On the basis of these data, it seems unlikely that triamterene could produce clinically significant hypercalcemia or hyperuricemia in nonazotemic patients. However, magnesium depletion could result from long‐continued use, especially when triamterene is combined with other diuretics which also increase magnesium excretion.