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Effect of methylphenidate on plasma anticonvulsant levels
Author(s) -
Kupferberg Harvey J.,
Jeffery William,
Hunninghake Donald B.
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972132201
Subject(s) - methylphenidate , primidone , anticonvulsant , phenobarbital , plasma levels , pharmacology , anesthesia , oral administration , plasma concentration , medicine , pharmacokinetics , epilepsy , attention deficit hyperactivity disorder , psychiatry
The effect of the oral administration of 30 mg. of methylphenidate daily on serum levels of phenobarbital, diphenylhydantoin, and primidone was evaluated in 11 patients. One group of patients was assigned to an 18 week treatment period of 6 weeks each for control, methylphenidate, and control; another group was studied in similar fashion for methylphenidate, control, and methylphenidate. Plasma anticonvulsant levels were determined at weekly intervals. No significant differences in plasma anticonvulsant levels were noted during methylphenidate administration.