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Effects of lithium on adrenergic function in man
Author(s) -
Fann William E.,
Davis John M.,
Janowsky David S.,
Cavanaugh John H.,
Kaufmann John S.,
Griffith John D.,
Oates John A.
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197213171
Subject(s) - lithium (medication) , tyramine , norepinephrine , mania , medicine , adrenergic , endocrinology , serotonin , chemistry , platelet , lithium chloride , pharmacology , bipolar disorder , dopamine , receptor , organic chemistry
Lithium is an effective agent in the treatment of mania. Since an abnormality of biogenic amines has been postulated to be a causative factor in mania and depression and since lithium has been found to alter biogenic amines in many animal systems, the effects of lithium on adrenergic function in man was investigated. The blood pressure response to infused norepinephrine (NE) and tyramine was investigated in 8 hypomanic patients who were studied during a control period and after 7 to 10 days of lithium treatment. Lithium decreased the pressor effect produced by NE by 22 ± 0.6 per cent. Lithium failed to alter the pressor effect to infused tyramine. Lithium failed to alter platelet serotonin content. Lithium decreased the pressor response to infused NE in man.