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Delay of erythema of human skin by anti‐inflammatory drugs after ultraviolet irradiation
Author(s) -
Gruber Charles M.,
Ridolfo Anthony S.,
Nickander Rodney,
Mikulaschek Walter M.
Publication year - 1972
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1972131109
Subject(s) - erythema , aspirin , medicine , anti inflammatory , nonsteroidal , antipyretic , pharmacology , dermatology , analgesic
Nonsteroidal, anti‐inflammatory, antipyretic analgesics have been demonstrated to delay the onset of the erythemic response to high‐intensity ultraviolet irradiation in albino guinea pigs. A similar phenomenon has been demonstrated in male Caucasian sub;ects and is used as a clinical screen for anti‐inflammatory activity. Single oral doses of aspirin, indomethacin, and fenoprofen ( dl ‐2‐[3‐phenoxyphenyl] propionic acid) have been evaluated. A sequential experimental design demonstrated activity for all three drugs. It is suggested that the method may be useful in evaluating anti‐inflammatory drugs.