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Blockade of intravenous amphetamine euphoria in man
Author(s) -
Jônsson Lars-Erik,
Änggård Erik,
Gunne Lars-M
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971126889
Subject(s) - euphoriant , amphetamine , blockade , medicine , dextroamphetamine , pharmacology , anesthesia , dopamine , psychiatry , receptor
In subjects who abuse amphetamine, the euphoric effect of 200 mg. of D,L‐amphetamine intravenously was reduced or abolished by oral pretreatment with α‐methyl‐p‐tyrosine (α‐MT) 2.0 to 4.0 Gm. The blockade of the amphetamine‐induced euphoria lasted for about 24 hours. After one week of daily administration of α‐MT, there was a reduction of the antiamphetamine effect. Three days after withdrawal, the renewed administration of α‐MT again caused a high degree of blockade of amphetamine‐induced euphoria.