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Technique of controlled drug assay in hypertension.; V. Comparison of hydrochlorothiazide with a new quinethazone diuretic, metolazone
Author(s) -
Pilewski Robert M.,
Scheib Eileen T.,
Misage John R.,
Kessler Edward,
Krifcher Emanuel,
Shapiro Alvin P.
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971125843
Subject(s) - hydrochlorothiazide , diuretic , uric acid , blood urea nitrogen , chemistry , blood sugar , transaminase , blood pressure , pharmacology , medicine , creatinine , endocrinology , biochemistry , enzyme , diabetes mellitus
The effects of two chemically different diuretic agents, hydrochlorothiazide and metolazone, a new quinethazone derivative, were studied in a group of 21 hypertensive patients. A change‐over, double‐blind design was used for 50 mg. of hydrochlorothiazide, 2.5 mg. of metolazone, and 5.0 mg. of metolazone. Body weight, blood pressure, blood urea nitrogen, electrolytes, uric acid, and blood sugar one hour after carbohydrate load were the measurements used to examine the efficacy of the drugs. Blood counts and serum glutamic oxalacetic transaminase also were monitored. The results showed no differences among the three treatments, but all showed the same significant response when compared to placebo for all measurements, except for blood counts, serum glutamic oxalacetic transaminase, and blood sugar.