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Effects of guancydine on systemic and renal hemodynamics in arterial hypertension
Author(s) -
Villarreal Herman,
Arcila Heriberto,
Ramirez Miguel Angel,
Sierra Pedro
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971125838
Subject(s) - medicine , blood pressure , hemodynamics , mean arterial pressure , nausea , anesthesia , renal function , renal blood flow , vomiting , heart rate , endocrinology
The effect of 1‐cyano‐3‐tert‐amylguanidine (guancydine) on systemic and renal hemodynamics was studied in patients with arterial hypertension. Antihypertensive drugs were withheld for 15 days prior to beginning of investigation. Average sodium intake was 105 mEq. per 24 hours in some patients and 25 mEq. per 24 hours in others. Patients were first on placebo during a control period averaging 14 days. Guancydine was given for 7 to 18 days at an average dose of 21 mg. per kilogram of body weight. Although mean arterial blood pressure decreased significantly in all patients, in only two did it reach normal levels. There was no change in cardiac output. Glomerular filtration rate and renal plasma flow remained unchanged while urinary sodium excretion diminished, suggesting a tubular effect. A substantial gain in body weight was noted. Nausea, vomiting, constipation, somnolence, restlessness, mental confusion, asthenia, and urine retention were observed. The antiangiotensin effect of guancydine described in animals was nut observed.