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Comparison of thioridazine and chlorpromazine in doctor's choice research design
Author(s) -
Kimbel Isham,
Overall John E.,
Winkelman George W.,
Hughes Waunell M.
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971125825
Subject(s) - thioridazine , chlorpromazine , placebo , antipsychotic , medicine , phenothiazine , pharmacology , schizophrenia (object oriented programming) , psychiatry , alternative medicine , pathology
A series of 156 patients selected by doctor's choice for treatment with either chlorpromazine or thioridazine was studied. The purposes of the investigation were to examine feasibility and utility of statistical control over extrinsic sources of variance in nonexperimental clinical research, to further the development of an adequate model for clinical research in natural treatment settings, and to evaluate possible specific differences in therapeutic indications of two widely used phenothiazine derivatives. From statistical analyses of the data, the results indicated that response to treatment depends on a number of nonspecific factors, some of which interact significantly with drtlg treatments. In the treatment of certain types of patients who have been reported in other studies to have generally favorable prognosis or to evidence good placebo response, chlorpromaZine and thioridazine appeared equally effective. In the treatment of types of patients that have not been reported to evidence such favorable nonspecific response, thioridazine appeared more effective. While both drugs are effective antipsychotic medications, the results from this study suggest that thioridazine may have a broader spectrum of activity.