Premium
Effects of placebo and flurazepam on sleep patterns in insomniac subjeets
Author(s) -
Kaies Joyce,
Kaies Anthony,
Bixler Edward O.,
Slye Elaine S.
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971124691
Subject(s) - flurazepam , placebo , anesthesia , sleep (system call) , sleep induction , sleep onset , medicine , hypnotic , non rapid eye movement sleep , electroencephalography , psychology , pharmacology , benzodiazepine , insomnia , psychiatry , receptor , pathology , computer science , operating system , alternative medicine
In 12 insomniac subiects placebo had no significant effects on sleep induction, sleep maintenance, or sleep stages, while flurazepam 30 mg. produced clear‐cut decreases in sleep latency, wake time after sleep onset, total wake time, and number of wakes. The decreases were maintained throughout the drug administration period as well as on the first several withdrawal nights, indicating a carry‐over effect. There was agreement between the subjectioe estimates of sleep and the electroencephalogram (EEG) data in terms of both improvement in sleep induction and sleep maintenance with flurazepam and in the lack of effects with placebo. Flurazepam produced either no change or a slight decrease in the percentage of rapid eye movement (REM) sleep, There were no increases above base line following withdrawal. Stages 3 and 4 sleep decreased considerably with drug administration, this decrease being maintained during the drug withdrawal period.