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Dose‐response analysis of the efJects of tetrahydrocannabinol in man
Author(s) -
Kiplinger Glenn F.,
Manno Joseph E.,
Rodda Bruce E.,
Forney Robert B.
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971124650
Subject(s) - dronabinol , tetrahydrocannabinol , heart rate , cannabis , mood , medicine , δ9 tetrahydrocannabinol , anesthesia , cannabinoid , psychiatry , blood pressure , receptor
Fifteen volunteers smoked marihuana cigarettes under controlled laboratory conditions on five occasions. The cigarettes were calibrated to deliver doses of 0, 6.25, 12.5, 25, and 50 εg per kilogram of Δ‐9‐tetrahydrocannabinol(THC). A randomized block, double‐blind design was used. It was found that motor and mental performance as well as stability of stance deteriorated in a linearly dose‐dependent fashion. Heart rate and corüunctioal redness increased with dose as did scores on sensation and mood questionnaires.