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The hypnotic effects of codeine and secobarbital and their interaction in man
Author(s) -
Bellville J. Weldon,
Forrest William H.,
Shroff Phyllis,
Brown Byron W.
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971124607
Subject(s) - secobarbital , codeine , hypnotic , anesthesia , stimulant , pharmacology , medicine , morphine , pentobarbital
Codeine and secobarbital and a combination of the two were studied as nighttime hypnotics. There was a positive dose effect between 60 and 180 mg. of secobarbital, but increasing the dose of codeine from 30 to 90 mg. appeared to show a stimulant effect on onset and duration of sleep. Taken together, codeine plus secobarbital were more effective than was secobarbital alone. Analysis indicated that this interaction represented synergism.