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Gas chromatography‐mass spectrometry of nortriptyline in body fluids of man
Author(s) -
Hammar Carl-Gustaf,
Alexanderson Balzar,
Holmstedt Bo,
Sjôqvist Folke
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971123496
Subject(s) - nortriptyline , chromatography , chemistry , mass spectrometry , elution , mass spectrum , gas chromatography–mass spectrometry , gas chromatography , drug , tricyclic antidepressant , antidepressant , pharmacology , medicine , amitriptyline , hippocampus
The application of the mass fragmentographic technique has aUowed accurate identification of a tricyclic antidepressant drug, nortriptyline, and some of its metabolites in biological fluids from patients treated with therapeutic doses and from one patient intoxicated with the same drug. Mass fragmentography in combination with the scanning of mass spectra of compoundy eluted from the gas chromatography column made it possible to identify nortriptyline and the metabolites, desmethylnortriptyline, 10‐hydroxynortriptyline, and, tentatively, 10‐hydroxydesmethylnortriptyline.