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A new method for assessing the clinical effects of oral analgesic drugs
Author(s) -
Jick Hershel,
Slone Dennis,
Shapiro Samuel,
Lewis George P.,
Siskind Victor
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971123456
Subject(s) - propoxyphene , medicine , placebo , analgesic , aspirin , drug , randomized controlled trial , clinical trial , adverse effect , intensive care medicine , anesthesia , pharmacology , alternative medicine , pathology
A randomized double‐blind trial comparing aspirin and a placebo in the treatment of mild to moderate pain was introduced into a comprehensive drug surveillance program. The program's standard methods of data collection were judgments of attending physicians on the efficacy and adverse effects of drugs. The napsylate and hydrochloride salts of propoxyphene were also compared. The already established effectiveness of aspirin was demonstrated. No evidence of a difference in efficacy between the two salts of propoxyphene was found. A randomized, double‐blind, large‐scale evaluation of certain marketed and unmarketed drugs within a comprehensive drug surveillance program is feasible and can be of considerable value in their clinical assessment.