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Dose response to codeine in patients with chronic cough
Author(s) -
Sevelius Hilli,
McCoy John F.,
Colmore John P.
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971123449
Subject(s) - codeine , medicine , placebo , chronic cough , anesthesia , dose–response relationship , placebo response , pharmacology , morphine , asthma , alternative medicine , pathology
A dose‐response curve for oral codeine phosphate was established in 12 adult male patients with chronic cough. The response measured was the per cent reduction in cough counts following 4 doses of codeine as compared to placebo. The curve of response on the log of the dose used was found to be linear, and a single oral dose of 15 to 20 mg. of codeine seemed to be optimum under the conditions of this study. No correlation between the objective cough counts and the patient's subiective evaluation of the drugs was established.