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A rapid method for the estimation of drug‐albumin affinity constants in human plasma
Author(s) -
Solomon Harvey M.,
Thomas Gordon B.
Publication year - 1971
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1971123445
Subject(s) - albumin , drug , plasma protein binding , chemistry , human serum albumin , human plasma , serum albumin , human albumin , blood proteins , chromatography , pharmacology , biochemistry , medicine
Many drugs are bound to a single site on human albumin, and the extent to which they bind may markedly infiuence their pharmacologic activities. The extent of binding of a drug to albumin depends, in part, upon the affinity of the protein for the drug (K AP ). A method is described for the rapid and accurate determination of the K AP of a drug from a single value of its concentration in plasma and extent of binding to albumin.