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Trials of Ro 5–3350 and diazepam for anxiety symptoms
Author(s) -
Mcleod William R.,
Mowbray Robert M.,
Davies Brian
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970116856
Subject(s) - diazepam , placebo , clinical trial , anxiety , medicine , placebo response , anesthesia , psychiatry , alternative medicine , pathology
Problems of assessment of antianxiety drugs are discussed and the use of small‐scale controlled preliminary clinical trials is suggested. Two such trials are described. In each the effects of the active substance were compared with placebo in persistently anxious patients with the use of a partially balanced design. In the first trial no differences wem found between Ro 5–3350 at 5 and 10 mg. 3 times a day and placebo. In the second trial conducted with similar patients and for the same length of time, different ratings of change were used, and diazepam was found to be superior to placebo.