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V. The architecture of clinical research (concluded)
Author(s) -
Feinstein Alvan R.
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970115755
Subject(s) - identification (biology) , architecture , computer science , population , state (computer science) , sequence (biology) , stage (stratigraphy) , management science , operations research , medicine , engineering , history , biology , programming language , environmental health , archaeology , botany , genetics , paleontology
In considering the design of a project in clinical research, we have thus far passed through five stages of biostatistical architecture. The first stage, concerned with the paramount principles of specifying the objective of the investigation, 19 contained the components and logic used for planning the sequence of initial state, maneuver , and subsequent state . The next four stages contained procedures for implementing the stated objective by delineating the intake, maintenance, initial identification, and subsequent identification of the population.20 This paper begins with the sixth stage of the design and continues through the remaining four operational principles that conclude this outline of biostatistical architecture for clinical research. Subsequent papers in this series will be devoted to additional methodologic issues that have been raised during the architectural discussions.