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Effect of L‐dopa alone and in combination with an extracerebral decarboxylase inhibitor on blood pressure and some cardiovascular reflexes
Author(s) -
Watanabe A. M.,
Chase T. N.,
Cardon P. V.
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970115740
Subject(s) - reflex , constriction , medicine , forearm , decarboxylase inhibitor , blood pressure , aromatic l amino acid decarboxylase , anesthesia , pharmacology , dopamine , levodopa , surgery , parkinson's disease , disease
L‐ Dopa produced a significant reduction in recumbent and standing blood pressure in patients with neurologic or psychiatric disorders. The addition of an extracerebral decarboxylase inhibitor potentiated this effect. Reflex forearm arteriolar and venous constriction was present during therapy with L‐ dopa alone or in combination with the decarboxylase inhibitor, but there was an attenuation of reflex forearm arteriolar constriction. It is suggested that the hypotensive effect of L‐ dopa may be mediated through the central nervous system .