Disappearance of phenobarbital and diphenylhydantoin from serum of children | Zendy

Garrettson L. K. | Zendy; Dayton P. G. | Zendy

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Disappearance of phenobarbital and diphenylhydantoin from serum of children

Author(s) -

Garrettson L. K.,

Dayton P. G.

Publication year - 1970

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt1970115674

Subject(s) - phenobarbital , primidone , phenytoin , anticonvulsant , epilepsy , medicine , serum concentration , chemistry , pharmacology , endocrinology , psychiatry

Children were treated for epilepsy with phenobarbital and diphenylhydantoin. In 2 cases, diphenylhydantoin could not be detected in the serum when combined with doses of phenobarbital above 1 mg. per kilogram per day. Other cases showed either a lowering of hydantoin levels or no change in the presence of phenobarbital. A method is presented which permits the quantitation of these two drugs and primidone from the same 0.5 ml. sample of serum. Serum half‐life of phenobarbital in 6 children was in the range of 37 to 73 hours. This is a lower range than that published for adults

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