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The effect of hydrochlorothiazide on venous reactivity in hypertensive man
Author(s) -
Ogilvie Richard I.,
Schlieper Eckart
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970114589
Subject(s) - hydrochlorothiazide , medicine , placebo , blood pressure , vasodilation , anesthesia , reactivity (psychology) , diastole , cardiology , alternative medicine , pathology
Peripheral venous reactivity was measured by the occluded limb technique in 14 subjects with essential hypertension during a single‐blind trial of hydrochlorothiazide (HCT) therapy. Venoconstriction in response to deep‐breath and Valsalva maneuvers decreased during HCT 150 mg. per day with a concommitant decrease in systemic blood pressure and serum potassium concentration. Further decreases in venous reactivity occurred during treatment with HCT 450 mg. per day which doubled serum HCT concentrations from that achieved on 150 mg. per day, and there was a further decrease in systolic but not diastolic blood pressures. Venous reactivity increased during placebo therapy after HCT. The venoconstriction responses of these hypertensive subjects during placebo therapy were not significantly different from those of 9 normotensive volunteers. The results show that there was a redu.ced response of the capacitance bed to neu.rogenic stimuli during HCT therapy.