Premium
Homatropine bradycardia in man
Author(s) -
Hayes Arthur H.,
Katz Richard A.
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970114558
Subject(s) - sinus bradycardia , bradycardia , medicine , heart rate , cardiology , body weight , anesthesia , blood pressure
Homatropine in doses of 0.5 to 4.0 mg. was administered subcutaneously to 8 medical students and .28 hospital patients following a double‐blind technique. At first there was dose‐related slowing of sinus heart rate; the 4 mg. dose was the turning pOint above which there usually was acceleration. Neither the magnitude nor the duration of the cardiac slowing correlated with age, sex, race, body weight, or control heart rate. Electrocardiographic changes were minimal, although prolonged atrioventricular conduction was noted in some subjects.