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Inhibition of apomorphine‐induced vomiting by benzquinamide
Author(s) -
Klein Rogelr L.,
Graves Constance L.,
Kim Yong,
Blatnick Richard
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970114530
Subject(s) - prochlorperazine , apomorphine , vomiting , antiemetic , medicine , anesthesia , adverse effect , nausea , oral administration , pharmacology , dopamine , dopaminergic
Benzquinamide was compared to prochlorperazine in apomorphine‐induced vomiting in healthy male volunteers. The antiemetic activity of benzquinamide by the oral route was significantly greater than that of 10 mg. of prochlorperazine. On the other hand, duration of action of benzquinamide was much shorter than that of prochlorperazine. Vomiting was not prevented except in a small percentage of the subjects 6 to 12 hours after oral administration of benzquinamide, while prochlorperazine was still effective. There were no adverse effects after benzquinamide. Benzquinamide is an effective antiemetic with rapid onset of action that deserves further clinical trial.