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Comparisons of effects of morphine, meperidine, fentanyl, and fentanyl‐droperidol
Author(s) -
Ordy J. M.,
Kretchmer H. E.,
Gorry T. H.,
Hershberger T. J.
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970114488
Subject(s) - fentanyl , droperidol , medicine , liter , anesthesia , morphine , analgesic , nausea
The specific aims of the double‐blind study were to compare the analgesic effectiveness of morphine (10 mg. per milliliter), meperidine (75 mg. per milliliter), fentanyl (0.1 mg. per milliliter), and fentanyl‐droperidol (0.1 to 2.5 mg. per milliliter) in patients subjected to routine medical and dental procedures at a metropolitan general hospital. The (4 x 3) analysis of variance design included the 4 drugs with observations on analgesia, vital signs, and blood chemistry 15, 30, or 45 minutes after drug infection. No significant differences in degree of relief from pain were observed among the 4 drugs or the 3 postinjection intervals. There was a significant interaction in the degree of relief by the 4 drugs with the 3 postinjection time intervals. The fentanyl‐droperidol combination provided a greater and more prompt degree of relief at 15 than at 30 or 45 minutes. Significant differences were not observed in manifest anxiety or frequency of nausea among the patients. No Significant differences were observed in vital signs, blood protein, glucose, cholesterol, or corticosterone levels among the 4 drug groups. Significant differences in blood glucose, cholesterol, and corticosterone were noted among the 3 postinjection time intervals.