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Kinetics of the anticoagulant effect of bishydroxycoumarin in man
Author(s) -
O'Reilly R. A.,
Levy Gerhard,
Keech Geraldine M.
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970113378
Subject(s) - warfarin , prothrombin time , chemistry , plasma concentration , linear relationship , inducer , kinetics , anticoagulant , pharmacology , chromatography , biochemistry , medicine , mathematics , statistics , physics , quantum mechanics , gene , atrial fibrillation
There is no direct relationship between the inhibition of prothrombin complex activity at any time and the plasma bishydroxycoumarin concentration at that time. It is shown that there is an essentially linear inverse relationship between synthesis rate of prothrombin complex activity and the logarithm of plasma bishydroxycoumarin concentration. This relationship is independent of the route of administration of the anticoagulant and is not affected by pretreatment with the microsomal enzyme inducer heptabarbital. There is a similar linear relationship between synthesis rate and log plasma concentration for warfarin. In subiects who yielded approximately parallel synthesis rate versus log plasma concentration regression lines for the two anticoagulants, warfarin was 6 to 10 times as potent as bishydroxycoumarin.