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Gentamicin sulfate distribution in body fluids
Author(s) -
Rodriguez Victorio,
Stewart Oorothy,
Bodey Gerald P.
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970112275
Subject(s) - gentamicin sulfate , gentamicin , medicine , toxicity , lymph , liter , aminoglycoside , anesthesia , pharmacology , chemistry , antibiotics , pathology , biochemistry
Pharmacological studies were conducted on patients receiving gentamicin sulfate intravenously. The mean peak serum level was 4.5 P,g per milliliter after the administration of 40 mg. per square meter gentamicin sulfate. The serum half‐life was approximately 2 hours and the decrease was exponential. There was no evidence of drug accumulation when administered at a dose of 30 mg. per square meter every 6 hours over a 10 day period. The concentration of gentamicin in thoracic duct lymph paralleled the simultaneous serum concentration. The drug did not diffuse readily into the cerebrospinal fluid. The intravenous administration of gentamicin was well tolerated and no unexpected toxicity was observed.