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Effects of antihypertensive drugs in the spontaneously hypertensive rat
Author(s) -
Tabei Ryo,
Spector Sydney,
Louis William J.,
Sjoerdsma Albert
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970112269
Subject(s) - blood pressure , medicine , spontaneously hypertensive rat , methyldopa , pharmacology , pargyline , antihypertensive drug , cardiology , receptor , serotonin
The spontaneously hypertensive rat is reported as a useful model to screen for antihypertensive drugs. Single doses of several d1"Ugs which have been useful therapeutically in man, including methyldopa and the MAO inhibitor pargyline, elicited a lowering of blood pressure in the spontaneously hypertensive animal. N ormotensive rats were generally unresponsive. For initial screening, indirect measurement of systolic blood pressure in the tail artery is recommended, but any changes observed should be validated by direct recording and possibly long‐term study.