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Atropine metabolism in man
Author(s) -
Kaiser Sarah C.,
McLain Paul L.
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970112214
Subject(s) - atropine , urine , chemistry , excretion , urinary system , metabolism , glucuronide , chromatography , endocrinology , pharmacology , medicine , biochemistry
Administration of two ¼C‐tropine‐labeled atropines to man shows the urinary excretion of 77 to 93 per cent of the injected dose in 24 hours. Only the N‐methyl‐¼C but not the 2,4‐14C‐atropine shows oxidation to HCO, with arespiratory elimination of 3 per cent in 3 hours. Atropine disappears very rapidly from the blood. Urinary excretion 01)er the first 24 hours occurs at two rates; a fast rate occurring first with a t½. of about 2 hours and a slow rate with a t½ of ab out 13 to 38 hours. The early urine samples show the major fraction of the HC existing as a chromatographic component which is a α‐glucuronide., The urines collected at later periods (4 to 8 hours) contain little, if any, of this component. The chromatographically distinguishable ¼C‐containing urinary components do not differ between the two HC‐atropines.