Premium
Guanadrel and guanethidine in hypertension
Author(s) -
Bloomfield Daniel K.,
Cangiano Jose L.
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1970112200
Subject(s) - guanethidine , supine position , medicine , anesthesia , surgery , stimulation
A modified double‐blind study was carried out in 40 patients with moderate to severe hypertensive disease. Twenty patients were treated with guanadrel in oral doses of 30 to 400 mg. daily for 17 weeks; the other 20 patients were treated with guanethidine in oral doses of 10 to 200 mg. daily for 14 weeks. Hypotensive actions were similar, but on a weight basis gttanadrel was only one third as potent as guanethidine. With gttanadrel there were positive responses in 60 per cent of patients in the supine position and 75 per cent of paUents in the erect position; with guanethidine there were positive responses in 55 per cent of patients in the supine position and 70 per cent of patients in the erect position.