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The diuretic action of an azido pyrimidine in man
Author(s) -
Johnson Brian F.
Publication year - 1970
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197011177
Subject(s) - diuretic , diuresis , chemistry , hydrochlorothiazide , excretion , endocrinology , uric acid , medicine , pharmacology , bicarbonate , proximal tubule , renal function , kidney , blood pressure
SC‐16l02, an azido pyrimidine, is a potent diuretic in rats but not dogs. In 6 inpatients maintained on a constant diet, 100 mg. of SC‐16l02 orally, showed a maximum diuretic effect in the first 2 hours. Minor increases in bicarbonate excretion and uric acid clearance were noted. Blood pressure and creatinine clearance were unchanged. In 8 hours there was significant weight loss. Although no toxic effects were noted, all subjects developed a mild, temporary polymorphonuclear leukocytosis. SC‐16l02 produces a pattern of diuresis similar to that of hydrochlorothiazide. lts predominant site of action is probably the proximal tubule, and it does not appear to inhibit mic acid excretion.