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Comparison of antihypertensive efficacy, intestinal absorption, and excretion of guanethidine in hypertensive patients
Author(s) -
Rahn K. Heinz,
Goldberg Leon I.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969106858
Subject(s) - guanethidine , excretion , urine , absorption (acoustics) , medicine , urinary system , blood pressure , chemistry , endocrinology , feces , pharmacology , gastroenterology , biology , stimulation , paleontology , physics , acoustics
Intestinal absorption and urinary excretion of guanethidine was determined in 6 patients with essential hypertension. Three of the patients had adequate reductions of standing diastolic blood pressure with 25 mg. per day of guanethidine (Group 1); the other 3 patients did not respond to 150 mg. per day of the drug (Group II). All patients also received a single oral dose of 41.6 mg. guanethidine‐ 14 C (5 pc). There was no significant difference between the two groups of patients with respect to rate of urinary excretion of radioactivity or the total amount of radioactivity excreted in the urine. The amount of radioactivity in the feces (reflecting unabsorbed drug) was similar in both groups. There was also no consistent difference noted in the urinary excretion of guanethidine metabolic fractions. These data indicate that poor intestinal absorption was not the cause of inadequate response to guanethidine in these patients.