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Effect of environmental factors on drug metabolism: Decreased plasma half‐life of antipyrine in workers exposed to chlorinated hydrocarbon insecticides
Author(s) -
Kolmodin Birgitta,
Azarnoff Daniel L.,
Sjöqvist Folke
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969105638
Subject(s) - lindane , drug metabolism , metabolism , drug , chemistry , microsome , plasma levels , toxicology , half life , pesticide , environmental chemistry , pharmacology , endocrinology , biochemistry , medicine , biology , pharmacokinetics , enzyme , agronomy
In twenty‐six men occupationally exposed to a mixture of insecticides, mainly lindane and DDT, antipyrine had a significantly shorter plasma half‐life than in 33 control sub;ects. If the mechanism is the same as that in animals, these studies indicate that insecticides can induce microsomal drug metabolism in man.