Effect of environmental factors on drug metabolism: Decreased plasma half‐life of antipyrine in workers exposed to chlorinated hydrocarbon insecticides | Zendy

Kolmodin Birgitta | Zendy; Azarnoff Daniel L. | Zendy; Sjöqvist Folke | Zendy

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Effect of environmental factors on drug metabolism: Decreased plasma half‐life of antipyrine in workers exposed to chlorinated hydrocarbon insecticides

Author(s) -

Kolmodin Birgitta,

Azarnoff Daniel L.,

Sjöqvist Folke

Publication year - 1969

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt1969105638

Subject(s) - lindane , drug metabolism , metabolism , drug , chemistry , microsome , plasma levels , toxicology , half life , pesticide , environmental chemistry , pharmacology , endocrinology , biochemistry , medicine , biology , pharmacokinetics , enzyme , agronomy

In twenty‐six men occupationally exposed to a mixture of insecticides, mainly lindane and DDT, antipyrine had a significantly shorter plasma half‐life than in 33 control sub;ects. If the mechanism is the same as that in animals, these studies indicate that insecticides can induce microsomal drug metabolism in man.

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