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Clinical trial of bitoscanate in hookworm disease
Author(s) -
Mutalik Gururaj S.,
Gulati Ravindra B.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969105635
Subject(s) - necator americanus , hookworm infection , hookworm infections , medicine , clinical trial , gastrointestinal tract , gastroenterology , surgery , helminths , immunology , ascaris lumbricoides
Bitoscanate was examined for clinical efficacy and safety in 30 hospitalized patients with hookworm infection due to Necator americanus. With 2 doses of 100 mg., each administered 12 hours apart after food, cure was obtained in 16 out of 30 patients. Egg reduction of over 95 per cent occurred in 90 per cent of the patients. The untoward effects observed were mild and limited to the gastrointestinal tract. There was no significant alteration of any of the laboratory tests performed.