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Effect of antimalarial drugs and collection methods on urinary and plasma 17‐hydroxycorticosteroid determinations
Author(s) -
Gilliland Paul F.,
Brooks Marion H.,
Bruton Joseph,
Barry Kevin G.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969104551
Subject(s) - quinine , pyrimethamine , chloroquine , hydroxycorticosteroids , pharmacology , urinary system , human plasma , urine , drug , medicine , malaria , chemistry , chromatography , immunology
Quinine, chloroquine, pyrimethamine, and sulforthodimethoxine, in concentrations comparable with levels observed in human plasma during therapeutic administration of these drugs, do not interfere with the Peterson method of determination of plasma 17‐hydroxycorticosteroids. Quinine concentrations achieved during administration to human beings do not interfere with determination of urinary 17‐hydroxycorticosteroids by a modified Porter‐Silber method.