Premium
The relationship between kanamycin pharmacokinetics: Distribution and renal function
Author(s) -
Orme Burton M.,
Cutler Ralph E.
Publication year - 1969
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1969104543
Subject(s) - kanamycin , inulin , renal function , volume of distribution , distribution volume , pharmacokinetics , chemistry , reabsorption , creatinine , renal physiology , distribution (mathematics) , extraction ratio , endocrinology , medicine , urology , kidney , pharmacology , chromatography , biochemistry , mathematics , antibiotics , mathematical analysis , extraction (chemistry)
In thirty‐four patients with either normal renal function or varying degrees of renal failure, simultaneous determinations of the renal clearance of inulin, para‐aminohippurate, creatinine, and kanamycin were made. In addition the volume of distribution of inulin and kanamycin was determined in 18 patients. No evidence for protein binding of kanamycin was found . .Although the exact tubular transport mechanisms are not clear, it is evident that net reabsorption occurs since the kanamycin clearance averaged 76 per cent of the inulin clearance and 60.4 per cent of the creatinine clearance. Kanamycin was distributed in a volume averaging 18.9 per cent of the body weight which closely approximated the inulin space. A formula for the serum half‐life of kanamycin is given.